Risk factors for non-specific low back pain in older people: a systematic review with meta-analysis

Risk factors for non-specific low back pain in older people: a systematic review with meta-analysis

Risk factors for non-specific low back pain in older people: a systematic review with meta-analysis
Abstract
Purpose
To conduct a systematic review about risk factors associated with non-specific low back pain (LBP) in older people.
Methods
The study protocol was prospectively registered with Prospero (CRD42020191619). This systematic review with meta-analysis included cohort studies that investigated risk factors for LBP in older people. The following databases were searched up to 12 December 2020: MEDLINE (Ovid), Embase, CINAHL, SCOPUS and Web of Science. Two independent reviewers appraised methodological quality using the Critical Appraisal Checklist for Cohort Studies instrument.
Results
We identified 3939 potentially relevant publications. After removing duplicates, screening title, and abstracts, we assessed 86 publications in full text. We included the remaining 11 publications for analysis. There is strong evidence that depressive symptoms are a risk of reporting future back pain onset (I2 = 52,7%, Odds ratio 1.4, CI 1.28–1.53).
Conclusion
Depressive symptoms are a risk factor for LBP in older people. Due to the limitations of the literature, the role of some risk factors remains unclear. An additional high-quality prospective cohort is needed to better elucidate these relationships.
This is a preview of subscription content, access via your institution .
Access options
Instant access to the full article PDF.
US$ 39.95
Tax calculation will be finalised during checkout.
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
US$ 119
Article   PubMed   Google Scholar  
2.
Wu A, March L, Zheng X, Huang J, Wang X, Zhao J, Blyth FM, Smith E, Buchbinder R, Hoy D (2020) Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017. Ann Transl Med 8(6):299. https://doi.org/10.21037/atm.2020.02.175
Article   PubMed   PubMed Central   Google Scholar  
3.
Rundell SD, Sherman KJ, Heagerty PJ, Mock CN, Jarvik JG (2015) The clinical course of pain and function in older adults with a new primary care visit for back pain. J Am Geriatr Soc 63(3):524–530. https://doi.org/10.1111/jgs.13241
Article   PubMed   Google Scholar  
4.
Stewart Williams J, Ng N, Peltzer K, Yawson A, Biritwum R, Maximova T, Wu F, Arokiasamy P, Kowal P, Chatterji S (2015) Risk factors and disability associated with low back pain in older adults in low- and middle-income countries. Results from the WHO Study on Global AGEing and Adult Health (SAGE). PLoS ONE 10(6):127880. https://doi.org/10.1371/journal.pone.0127880
CAS   Article   Google Scholar  
5.
do Carvalho NPR, Ferreira ML, Poitras S, Bilodeau M (2019) Exclusion of older adults from ongoing clinical trials on low back pain: a review of the WHO Trial Registry Database. J Am Geriatr Soc 67(3):603–608. https://doi.org/10.1111/jgs.15684
Article   Google Scholar  
6.
Paeck T, Ferreira ML, Sun C, Lin CW, Tiedemann A, Maher CG (2014) Are older adults missing from low back pain clinical trials? A systematic review and meta-analysis. Arthritis Care Res 66(8):1220–1226. https://doi.org/10.1002/acr.22261
Article   Google Scholar  
7.
Felício DC, Diz JBM, Pereira DS, Queiroz BZ, Silva JP, Moreira BS et al (2017) Handgrip strength is associated with, but poorly predicts, disability in older women with acute low back pain: a 12-month follow-up study. Maturitas 104:19–23. https://doi.org/10.1016/j.maturitas.2017.07.006
Article   PubMed   Google Scholar  
8.
Kherad M, Rosengren BE, Hasserius R, Nilsson JÅ, Redlund-Johnell I, Ohlsson C, Mellström D, Lorentzon M, Ljunggren Ö, Karlsson MK (2017) Risk factors for low back pain and sciatica in elderly men-the MrOS Sweden study. Age Ageing 46(1):64–71. https://doi.org/10.1093/ageing/afw152
Article   PubMed   Google Scholar  
9.
Yip YB, Ho SC, Chan SG (2001) Socio-psychological stressors as risk factors for low back pain in Chinese middle-aged women. J Adv Nurs 36(3):409–416. https://doi.org/10.1046/j.1365-2648.2001.01988.x
CAS   Article   PubMed   Google Scholar  
10.
Yip YB, Ho SC, Chan SG (2004) Identifying risk factors for low back pain (LBP) in Chinese middle-aged women: a case-control study. Health Care Women Int 25(4):358–369. https://doi.org/10.1080/07399330490278367
CAS   Article   PubMed   Google Scholar  
11.
Wong AY, Karppinen J, Samartzis D (2017) Low back pain in older adults: risk factors, management options and future directions. Scoliosis Spinal Disord 18(12):14. https://doi.org/10.1186/s13013-017-0121-3
Article   Google Scholar  
12.
Van Tulder M, Furlan A, Bombardier C et al (2003) Updated method guidelines for systematic reviews in the cochrane collaboration back review group. Spine 28:1290–1299. https://doi.org/10.1097/01.brs.0000065484.95996.af
Article   PubMed   Google Scholar  
13.
Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, Currie M, Lisy K, Qureshi R, Mattis P, Mu P. (2020) Systematic reviews of etiology and risk. In: Aromataris E, Munn Z (eds) JBI manual for evidence synthesis. https://doi.org/10.46658/JBIMES-20-08
14.
Docking RE, Fleming J, Brayne C, Zhao J, Macfarlane GJ, Jones GT (2011) Epidemiology of back pain in older adults: prevalence and risk factors for back pain onset. Rheumatol 50(9):1645–1653. https://doi.org/10.1093/rheumatology/ker175
Article   Google Scholar  
15.
Hartvigsen J, Christensen K, Frederiksen H (2003) Back pain remains a common symptom in old age. A population-based study of 4486 Danish twins aged 70–102. Eur Spine J 12(5):528–5534. https://doi.org/10.1007/s00586-003-0542-y
Article   PubMed   PubMed Central   Google Scholar  
16.
Hartvigsen J, Christensen K, Frederiksen H, Pedersen HC (2004) Genetic and environmental contributions to back pain in old age—a study of 2,108 Danish twins aged 70 and older. Spine 29(8):897–901. https://doi.org/10.1097/00007632-200404150-00015
Article   PubMed   Google Scholar  
17.
Hartvigsen J, Frederiksen H, Christensen K (2006) Physical and mental function and incident low back pain in seniors—a population-based two-year prospective study of 1387 Danish twins aged 70 to 100 years. Spine 31(14):1628–1632. https://doi.org/10.1097/01.brs.0000222021.00531.ea
Article   PubMed   Google Scholar  
18.
Hartvigsen J, Christensen K (2007) Active lifestyle protects against incident low back pain in seniors: a population-based 2-year prospective study of 1387 Danish twins aged 70–100 years. Spine 32(1):76–81. https://doi.org/10.1097/01.brs.0000250292.18121.ce
Article   PubMed   Google Scholar  
19.
Hubscher M, Hartvigsen J, Fernandez M, Christensen K, Ferreira P (2016) Does physical activity moderate the relationship between depression symptomatology and low back pain? Cohort and co-twin control analyses nested in the longitudinal study of aging Danish twins (LSADT). Eur Spine J 25(4):1226–1233. https://doi.org/10.1007/s00586-015-4138-0
Article   PubMed   Google Scholar  
20.
Jacobs JM, Hammerman-Rozenberg R, Cohen A, Stessman J (2006) Chronic back pain among the elderly: prevalence, associations, and predictors. Spine 31(7):E203–E207. https://doi.org/10.1097/01.brs.0000206367.57918.3c
Article   PubMed   Google Scholar  
21.
Makris UE, Fraenkel L, Han L, Leo-Summers L, Gill TM (2014) Risk factors for restricting back pain in older persons. J Am Med Dir Assoc 15(1):62–67. https://doi.org/10.1016/j.jamda.2013.09.013
Article   PubMed   Google Scholar  
22.
Meyer T, Cooper J, Raspe H (2007) Disabling low back pain and depressive symptoms in the community-dwelling elderly—a prospective study. Spine 32(21):2380–2386. https://doi.org/10.1097/brs.0b013e3181557955
Article   PubMed   Google Scholar  
23.
Parreira PCS, Maher CG, Ferreira ML, Machado GC, Blyth FM, Naganathan V et al (2017) A longitudinal study of the influence of comorbidities and lifestyle factors on low back pain in older men. Pain 158(8):1571–1576. https://doi.org/10.1097/j.pain.0000000000000952
Article   PubMed   Google Scholar  
24.
Reid MC, Williams CS, Concato J, Tinetti ME, Gill TM (2003) Depressive symptoms as a risk factor for disabling back pain in community-dwelling older persons. J Am Geriatr Soc 51(12):1710–1717. https://doi.org/10.1046/j.1532-5415.2003.51554.x
Article   PubMed   Google Scholar  
26.
Carroll LJ, Cassidy JD, Cote P (2004) Depression as a risk factor for onset of an episode of troublesome neck and low back pain. Pain 107:134–139. https://doi.org/10.1016/j.pain.2003.10.009
Article   PubMed   Google Scholar  
27.
Sohrab A, Sepideh B, Esfandiar A (2020) Back pain and depressive symptoms: a systematic review and meta-analysis. Int J Psychiatry Med 27:91217420913001. https://doi.org/10.1177/0091217420913001
Article   Google Scholar  
28.
Manchikanti L, Singh V, Datta S, Cohen SP, Hirsch JA (2009) Comprehensive review of epidemiology, scope, and impact of spinal pain. Pain Physician 12(4):E35-70 (PMID: 19668291)
Article   Google Scholar  
29.
Demyttenaere K, Bruffaerts R, Lee S, Posada-Villa J, Kovess V, Angermeyer MC et al (2007) Mental disorders among persons with chronic back or neck pain: results from the World Mental Health Surveys. Pain 129(3):332–342. https://doi.org/10.1016/j.pain.2007.01.022
Article   PubMed   Google Scholar  
30.
Øiestad BE, Hilde G, Tveter AT, Peat GG, Thomas MJ, Dunn KM, Grotle M (2020) Risk factors for episodes of back pain in emerging adults. A systematic review. Eur J Pain 24(1):19–38. https://doi.org/10.1002/ejp.1474
Article   PubMed   Google Scholar  
31.
Taylor JB, Goode AP, George SZ, Cook CE (2014) Incidence and risk factors for first-time incident low back pain: a systematic review and meta-analysis. Spine J 14:2299–2319. https://doi.org/10.1016/j.spinee.2014.01.026
Article   PubMed   Google Scholar  
32.
Messing RB, Lytle LD (1977) Serotonin-containing neurons: their possible role in pain and analgesia. Pain 4(1):1–21. https://doi.org/10.1016/0304-3959(77)90083-5

Images Powered by Shutterstock